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KMID : 0043319990220060608
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Archives of Pharmacal Research
1999 Volume.22 No. 6 p.608 ~ p.613
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Chiral Separation of β-Blockers after Derivatization with (-)-Menthyl chloroformate by Reversed-Phase High Performance Liquid Chromatography
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Kim Kyeong-Ho
Choi Pok-Wha
Hong Seon-Pyo
Kim Hyun-Ju
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Abstract
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Optimum conditions of chiral derivatization reaction of -blockers (acebutolol, arotinolol, betaxolol, bisoprolol, celiprolol, metoprolol and pindolol) with (-)-menthyl chloroformate were investigated for the resolution by HPLC. With more than 30 times molar excess of (-)-methyl chloroformate chiral derivatization reactions were completed within one hour at room temperature except arotinolol and celiprolol. Diastereomeric derivatives of -blockers were well resolved on the ODS column using acetonitrile-methanol-water as a mobile phase.
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KEYWORD
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Chiral derivatization, β-Blocker, Resolution, (-)-Menthyl chloroformate
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